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Cardiac Biomechanics Lab »  People »  Principal Investigators »  Mark Ratcliffe, M.D.
Mark Ratcliffe, M.D.

Mark Ratcliffe, M.D.

Professor of Surgery
Division of Adult Cardiothoracic Surgery, UCSF
Co-Director, Cardiac Biomechanics Lab

Contact Information

4150 Clement Street
San Francisco, CA  94121
tel: 415-750-2057
fax: 415-750-2181

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  • M.D.-Case Western Reserve University, Cleveland, OH
  • B.A. - Denison University, Granville, OH
  • Internship - John Hopkins Hospital, Baltimore, MD
  • Residency - John Hopkins Hospital, Baltimore, MD
  • Residency - University of Pennsylvania Hospital, Philadelphia, PA
  • Research Fellow - University of Pennsylvania Hospital, Philadelphia, PA
  • Fellowship - University of Pennsylvania Hospital, Philadelphia, PA
  • American Board of Surgery, 1989
  • American Board of Thoracic Surgery, 1993
  • Minimally invasive cardiac surgery
  • Off-pump coronary artery bypass surgery
  • Robotic surgery
  • Surgery for heart failure
  • Thoracic aortic surgery
  • Valve repair and replacement
  • Finite element analysis of failing left ventricle

Dr. Ratcliffe received his M.D. degree from Case Western Reserve School of Medicine and completed his General Surgery and Cardiothoracic residencies at the Univeristy of Pennsylvania. Dr. Ratcliffe is certified by the American Board of Surgery and American Board of Thoracic Surgery. His special interest is in the application of finite element analysis or the failing left ventricle. Dr. Ratcliffe has been on the faculty since 1993. Currently, he is Director of the Cardiac Biomechanics Laboratory.

Dr. Ratcliffe is an active member of the American Society for Artificial Internal Organs, American Heart Association, Society of Thoracic Surgeons, Western Thoracic Surgical Association, San Francisco Surgical Society, American Association of Thoracic Surgery, and is a Fellow of the American College of Surgeons.

Publications provided by UCSF Profiles, powered by CTSI.
  1. Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB. Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility. J Biomed Mater Res A. 2020 Apr 08. View in PubMed
  2. Zhang Y, Wang VY, Morgan AE, Kim J, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB. A Novel MRI-Based Finite Element Modeling Method for Calculation of Myocardial Ischemia Effect in Patients With Functional Mitral Regurgitation. Front Physiol. 2020; 11:158. View in PubMed
  3. Kim J, Palumbo MC, Khalique OK, Rong LQ, Sultana R, Das M, Jantz J, Nagata Y, Devereux RB, Wong SC, Bergman GW, Levine RA, Ratcliffe MB, Weinsaft JW. Transcatheter MitraClip repair alters mitral annular geometry - device induced annular remodeling on three-dimensional echocardiography predicts therapeutic response. Cardiovasc Ultrasound. 2019 Dec 26; 17(1):31. View in PubMed
  4. Zhang Y, Wang VY, Morgan AE, Kim J, Handschumacher MD, Moskowitz CS, Levine RA, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB. Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation - A finite element modeling study. PLoS One. 2019; 14(10):e0223472. View in PubMed
  5. Planchard D, Garassino MC, Paz-Ares L, Faivre-Finn C, Spira A, Gu Y, Wadsworth C, Whiteley J, Scott M, Boothman AM, Ratcliffe M, Walker J, Dennis PA, Antonia SJ. Prevalence of programmed death ligand-1 (PD-L1) by demographic, disease and sample characteristics in unresectable, stage III NSCLC (PACIFIC). Ann Oncol. 2019 Apr; 30 Suppl 2:ii32-ii33. View in PubMed
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