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Cardiac Biomechanics Lab

Welcome to the Cardiac Biomechanics Lab Site

 Our lab uses state of the art mechanical engineering analysis to determine the cause and to design treatments for the ventricular remodeling and heart failure that occurs after myocardial infarction.

Areas of Focus

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Recent Publications

Carrick R, Ge L, Lee LC, Zhang Z, Mishra R, Axel L, Guccione JM, Grossi EA, Ratcliffe MB
Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: importance of residual stress.
The Annals of thoracic surgery, Jun-01-2012; 936: 1964-71.  Epub 2012 May 5.
Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L
The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation.
The Annals of thoracic surgery, Mar-01-2012; 933: 776-82.  Epub 2012 Jan 15.
Wenk JF, Ge L, Zhang Z, Soleimani M, Potter DD, Wallace AW, Tseng E, Ratcliffe MB, Guccione JM
A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.
Computer methods in biomechanics and biomedical engineering, Jan-16-2012; [Epub ahead of print].
Wall ST, Guccione JM, Ratcliffe MB, Sundnes JS
Electromechanical feedback with reduced cellular connectivity alters electrical activity in an infarct injured left ventricle: a finite element model study.
American journal of physiology. Heart and circulatory physiology, Jan-01-2012; 3021: H206-14.  Epub 2011 Nov 4.
Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB
The benefit of enhanced contractility in the infarct borderzone: a virtual experiment.
Frontiers in physiology, 3: 86.
Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB
Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction.
The Annals of thoracic surgery, Nov-01-2011; 925: 1614-20.  Epub 2011 Sep 25.
Chitsaz S, Jaussaud N, Chau E, Yan KS, Azadani AN, Ratcliffe MB, Tseng EE
Operative risks and survival in veterans with severe aortic stenosis: surgery versus medical therapy.
The Annals of thoracic surgery, Sep-01-2011; 923: 866-72.
Wenk JF, Eslami P, Zhang Z, Xu C, Kuhl E, Gorman JH, Robb JD, Ratcliffe MB, Gorman RC, Guccione JM
A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction.
The Annals of thoracic surgery, Sep-01-2011; 923: 935-41.
Lee LC, Wenk JF, Klepach D, Zhang Z, Saloner D, Wallace AW, Ge L, Ratcliffe MB, Guccione JM
A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction.
Journal of biomechanical engineering, Sep-01-2011; 1339: 094506.
Wenk JF, Sun K, Zhang Z, Soleimani M, Ge L, Saloner D, Wallace AW, Ratcliffe MB, Guccione JM
Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction.
Journal of biomechanical engineering, Apr-01-2011; 1334: 044501.
Zhang Z, Tendulkar A, Sun K, Saloner DA, Wallace AW, Ge L, Guccione JM, Ratcliffe MB
Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling.
The Annals of thoracic surgery, Jan-01-2011; 911: 150-6.
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